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Melphalan treats only the symptoms of ovarian cancer or multiple myeloma, but does not treat the cancer itself.

Important Information

Melphalan can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).

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You should not use melphalan if you are allergic to it, or if prior treatment with this medication was unsuccessful in controlling your disease.

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a weak immune system (caused by disease or by using certain medicine);
liver disease;
kidney disease; or
a history of chemotherapy or radiation.

Using melphalan may increase your risk of developing other types of cancer, such as leukemia. Ask your doctor about your specific risk.

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This medication may affect fertility (your ability to have children), whether you are a man or a woman.

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Oral melphalan is a tablet you take by mouth. Injectable melphalan is injected into a vein through an IV. A healthcare provider will give you this injection.

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What happens if I miss a dose?

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What should I avoid while taking melphalan?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Do not receive a "live" vaccine while using melphalan. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

melphalan can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

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bone marrow suppression--sudden weakness or ill feeling, fever, chills, pale skin, easy bruising or bleeding, red or pink urine, painful mouth sores, cough, trouble breathing, feeling light-headed, rapid heart rate;
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