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Continued approval for these sensitive substrates in their approved labeling. Patients across both arms received a median of three prior lines of therapy, including a BTK inhibitor INDIANAPOLIS, Dec. Pirtobrutinib was developed to reversibly bind BTK, deliver consistently high target coverage regardless of BTK turnover rate, and preserve activity in the B-cell antigen receptor signaling pathway, which is required for the development, activation, and survival of normal white blood cells known as B-cells, and malignant B-cells.

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