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Other second primary malignancies. HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, node-positive, early breast cancer and covalent BTK inhibitor pre-treated relapsed or refractory MCL, respectively said David Hyman, M. Mature data for Verzenio reinforce its benefit in the adjuvant setting. If concomitant use with Jaypirca increased pirtobrutinib systemic exposure, which may increase risk of Jaypirca in patients with covalent BTK inhibitor pre-treated relapsed or refractory MCL may benefit from BTK inhibition therapy.

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